Projects

Below is a list of projects that are making use of the Tayside Biorepository:

Latest Projects

Blood supply and innervation of the prostate: Improving clinical outcomes of radical prostatectomy

Lead Applicant: Ghazi Alanazi

July 2017

LGR5 in Oesophagel Squamous Cell Carcinoma

Lead Applicant: Russell Petty

May 2017

Next Generation Sequencing of Oesophageal Adenocarcinoma Exceptional Chemotherapy Responders

Lead Applicant: Russell Petty

May 2017

Investigating EMSY immunostaining in cancer tissues

Lead Applicant: Sara Brown

April 2017

Development of Diagnostic Tests for Protease Biomarkers of Respiratory Disease

Lead Applicant: Kelly Moffitt

March 2017

Development of Diagnostic Tests for Protease Biomarkers of Respiratory Disease

Lead Applicant: Kelly Moffitt

March 2017

Characterisation of EGFR FISH positive Oesophageal Cancer

Lead Applicant: Russell Petty

March 2017

Exploring the role of Neutrophil Extracellular Traps (NETs) in the pathogenesis of Non Alcoholic Fatty Liver Disease (NAFLD)

Lead Applicant: Michael Miller

February 2017

Validation of inflammatory mediators in cutaneous SCC

Lead Applicant: C Proby

January 2017

The pulmonary mycobiome in Bronchiectasis

Lead Applicant: Sanjay Chotirmall

January 2017

Pharmacogenomics in Childhood Asthma

Lead Applicant: Anke H. Maitland-van der Zee

January 2017

Periprostatic Fat Characterisation as a Marker of Prostate Cancer Aggressiveness

Lead Applicant: Naief Dahran

December 2016

Chromosome copy number variation in collecting duct carcinoma

Lead Applicant: Stewart Fleming

December 2016

Pre-clinical evaluation of novel combination therapies for Glioblastoma

Lead Applicant: Kismet Hossain-Ibrahim

December 2016

Pre-clinical evaluation of novel combination therapies for Glioblastoma

Lead Applicant: Kismet Hossain-Ibrahim

December 2016

Pre-clinical evaluation of novel combination therapies for Glioblastoma

Lead Applicant: Kismet Hossain-Ibrahim

December 2016

Pre-clinical evaluation of novel combination therapies for Glioblastoma

Lead Applicant: Kismet Hossain-Ibrahim

December 2016

Development of novel assay to measure disease specific biomarkers in a phase 1 trial of 264RAD therapy

Lead Applicant: Claudia Prevosto

November 2016

Investigating a role of BACE1 in vascular function

Lead Applicant: paul meakin

November 2016

Impact of OCT1 Genotype and OCT1 Inhibiting Drugs on an Individual

Lead Applicant: Laura McCreight

November 2016

Association of intravesical recurrence with ureteroscopic biopsy of upper tract urothelial carcinoma: confirmation of clonal relationship by array-based comparative genomic hybridisation.

Lead Applicant: Thineskrishna Anbarasan

October 2016

Fusion genes in liver cancer

Lead Applicant: Dr Rajai AL-Jehani

October 2016

Proteogenomic Landscaping of Oesophageal Cancer

Lead Applicant: Russell Petty

September 2016

Identification of in-vivo generated human autoantibodies for the screening and early detection of primary colorectal cancer (CRC)

Lead Applicant: Professor John Robertson

September 2016

Cutaneos SCC:Translation from molecular candidates to therapeutic targets

Lead Applicant: Dr Sharon King

August 2016

PPAR delta and COX-2 as predictors of outcome in pancreatic carcinoma

Lead Applicant: Douglas Adamson

July 2016

Proteomic characterisation of the SWI/SNF chromatin remodelling complex in tumour tissue

Lead Applicant: Tom Owen-Hughes

July 2016

Cutaneous SCC: Translation from molecular candidates to therapeutic targets

Lead Applicant: C Proby

July 2016

Cutaneous SCC: Translation from molecular candidates to therapeutic targets

Lead Applicant: C Proby

July 2016

Cutaneous SCC: Translation from molecular candidates to therapeutic targets

Lead Applicant: C Proby

June 2016

Expression of ezrin and related proteins in laryngeal epithlium

Lead Applicant: Kirsty Morley

June 2016

Pharmacokinetics of Metformin Intolerance

Lead Applicant: Laura McCreight

June 2016

Microultrasound characterisation of gastrointestinal tissue

Lead Applicant: Benjamin F Cox

May 2016

Analysis of p53 isoform protein expression in tumours

Lead Applicant: jean-christophe bourdon

May 2016

ICGC breast cancer genome sequencing

Lead Applicant: Colin Purdie

May 2016

Development of a dual immunofluorescence staining method for pro-inflammatory mediators.

Lead Applicant: Ruth Plummer

April 2016

Evaluation of the methodology for isolating and testing circulating tumour DNA

Lead Applicant: David Baty

April 2016

Evaluation of the methodology for isolating and testing circulating tumour DNA

Lead Applicant: David Baty

April 2016

TRIM24 expression in breast cancer

Lead Applicant: Alastair M Thompson

April 2016

TP53 sequencing for patients with chronic lymphocytic leukaemia (CLL)

Lead Applicant: Sudhir Tauro

March 2016

“Biological & Epidemiological insights into HPV related oropharyngeal cancers. The microbial dimension.”

Lead Applicant: David Edwards

March 2016

contract research investigations for dermal bioavailability and toxicology

Lead Applicant: Craig Moore

February 2016

Investigating genetic mechanisms in atopic eczema

Lead Applicant: Sara Brown

February 2016

Studies on isolated fresh gastrointestinal tissues to investigate new medicines

Lead Applicant: David Bunton

February 2016

Structure and composition of bladder cancer organoids

Lead Applicant: Scott Palmer

January 2016

Staining of triple negative breast cancers for TIL markers

Lead Applicant: Frances Fuller-Pace

January 2016

A Feasibility and Method Optimsiation Study in Oesophegal Cancer Proteomics

Lead Applicant: Russell Petty

January 2016

Immunohistochemistry of the synovium, posterior cruciate and meniscofemoral ligaments in the knee joint.

Lead Applicant: MOHAMMAD ALOBAIDY

December 2015

“Profiling the expression of key glycosylation enzymes in pancreatic ductal adenocarcinomas and triple negative breast cancers”

Lead Applicant: Dr Jennifer Fraser

December 2015

Discrimination of ex-vivo normal colon and colonic adenocarcinoma using combined wavelength-modulated Raman spectroscopy and optical coherence tomography (OCT)

Lead Applicant: C Simon Herrington

December 2015

YAP1 expression in HER2 positive Breast Cancer

Lead Applicant: Beatrix Elsberger

December 2015

Cellular and molecular characterisation of rarer acute myeloid leukaemias

Lead Applicant: Sudhir Tauro

November 2015

Investigating a role of BACE1 in atherosclerosis

Lead Applicant: paul meakin

November 2015

Variation of p53 isoforms rexpression in CLL patients treated by chemotherapy

Lead Applicant: jean-christophe bourdon

October 2015

Studies on isolated fresh skin samples to investigate new medicines

Lead Applicant: David Bunton

October 2015

Identification of metabolic vulnerabilities of renal cell carcinoma

Lead Applicant: Henry Däbritz

September 2015

Periprostatic Fat Characterisation as a Marker of Prostate Cancer Aggressiveness

Lead Applicant: Naief Dahran

September 2015

To assess the clinical performance of a new test for diagnosis of Rheumatoid arthritis

Lead Applicant: Anil Vasishta

September 2015

Validation Cohort: Proteomic and Genomic Analysis of Inflammatory Bowel Disease Associated Colorectal Cancers

Lead Applicant: Dr Shahida Din

August 2015

contract research investigations for dermal bioavailability and toxicology

Lead Applicant: Craig Moore

August 2015

Molecular mechanisms in atopic eczema

Lead Applicant: Sara Brown

August 2015

multibiomaker evaluation of response to radiotherapy in normal breast tissue

Lead Applicant: alastair Thompson

March 2015

Xray diffraction of breast tumours and the peritumoural tissues: a feasibility study

Lead Applicant: Dr Sarah Vinnicombe

January 2015

Measuring downstream targets of ERbeta in breast cancer

Lead Applicant: alastair Thompson

January 2015

YAP1 signalling in HER2 positive breast cancer

Lead Applicant: Beatrix Elsberger

January 2015

Regulation of PIM kinase levels in Chronic Lymphocytic Leukaemia

Lead Applicant: Lucy Littlejohn

January 2015

Osteopontin as a tumour marker of prostatic cancer and the survival rate

Lead Applicant: Abduelmenem Alashkham

January 2015

Sirtuin/nicotinamide adenine dinucleotide pathway: links with inflammation, obesity and colorectal cancer

Lead Applicant: Janice Drew

December 2014

Investigating the role of MSR1 copy number variation in Kalikrein Gene expression in breast cancer.

Lead Applicant: Jonathan Berg

December 2014

Laboratory based isolation and growth of normal skin, breast and adipose cells from redundant tissue

Lead Applicant: C Proby

November 2014

The effect of HLA-Cw6 status on treatment outcome with MTX in psoriasis patients

Lead Applicant: John Foerster

November 2014

Validation of DNA profiling from archival material

Lead Applicant: Stewart Fleming

October 2014

Molecular Pathogenesis of Cutaneous Squamous Cell Carcinoma - Mutational Profiling of Precursor Lesions

Lead Applicant: Aidan Rose

October 2014

The analysis of novel biomarkers in metastatic melanoma

Lead Applicant: David Meek

October 2014

Validation of Biomarker Candidates for Colorectal Cancer Screening

Lead Applicant: Jeffrey Huang

July 2014

Peri-tumoural biomarkers of vascular invasion and nodal metastases in breast cancer

Lead Applicant: andrew evans

July 2014

Improving the rate of detection of histological parameters affecting prognosis in oral squamous cell carcinoma.

Lead Applicant: Richard Oparka

July 2014

Improving the rate of detection of histological parameters affecting prognosis in oral squamous cell carcinoma.

Lead Applicant: Richard Oparka

July 2014

Laboratory based isolation and growth of normal skin, breast and adipose cells from redundant tissue

Lead Applicant: C Proby

July 2014

Perineural spread in head and neck cancer

Lead Applicant: Huda Alkhdar

July 2014

Molecular Pathogenesis of Cutaneous Squamous Cell Carcinoma

Lead Applicant: Aidan Rose

June 2014

Biomarkers of NRF2 activation in NSCLC

Lead Applicant: Kenny MacLeod

June 2014

Studies on isolated fresh diseased colorectal tissue to investigate new medicines

Lead Applicant: David Bunton

June 2014

Investigating a role of BACE1 in inflammatory vascular disease

Lead Applicant: paul meakin

April 2014

Development of molecular therapies for genodermatoses.

Lead Applicant: Irwin McLean

March 2014

Analysis of APAF-1 and DAPK-1 in UT-TCC as correlated with clinical outcome

Lead Applicant: Fionnuala Hinds

March 2014

Genetic mechanisms in eczema pathogenesis

Lead Applicant: Sara Brown

March 2014

Using Low Penetrance Genetic Loci in Colorectal Cancer Screening

Lead Applicant: Jessica Dalzell

February 2014

To confirm the solid tissue staining capabilities of a novel antibody MCM2 in the determination of malignancy in bladder tissue.

Lead Applicant: Bensita Bernard

February 2014

Role of FAM60A in colorectal cancer TR000366-extension

Lead Applicant: Sonia Rocha

January 2014

Investigating the molecular mechanism of anti-NMDA encephalitis

Lead Applicant: Dr Sharon King

January 2014

Supply of residual Clinical Samples for use in the Development of In Vitro Diagnostic Products

Lead Applicant: Peter Kelly

January 2014

Studies on isolated tissues to investigate new medicines

Lead Applicant: David Bunton

January 2014

Procurement of Adipocyte Derived Mesenchymal Cells

Lead Applicant: John Biddlestone

January 2014

Creation of Breast Cancer TMA

Lead Applicant: Frances Fuller-Pace

December 2013

Does the type VII secretory system of Staphylococcus aureus contribute to virulence and colonisation in the skin?

Lead Applicant: Dr. Catriona P.Harkins

December 2013

Molecular Pathogenesis of Cutaneous Squamous Cell Carcinoma

Lead Applicant: Aidan Rose

December 2013

Identification of Tumour-Associated Macrophages in Ovarian Tumours

Lead Applicant: Dr Michael Salako

November 2013

Investigating the Clinicopathological significance of Pim-kinase expression in T-cell non Hodgkin’s lymphoma

Lead Applicant: Maninee Purohit

October 2013

Significance of chromosome 9p deletion in renal cell carcinoma

Lead Applicant: Stewart Fleming

October 2013

ADFP in renal cell carcinoma

Lead Applicant: Stewart Fleming

October 2013

Molecular Pathogenesis of Cutaneous Squamous Cell Carcinoma

Lead Applicant: Aidan Rose

September 2013

G-protein coupled receptors in obesity and metabolic health

Lead Applicant: Janice Drew

September 2013

Scottish Diabetes Research Network: Type 1 Bioresource

Lead Applicant: Helen Colhoun

August 2013

Provision of Gastric Tumour and Normal tissue samples to The Cancer Genome Atlas (TCGA) initiative

Lead Applicant: C Simon Herrington

August 2013

Additional request for TR0168

Lead Applicant: Frank Carey

July 2013

The use of Thiel embalmed cadavers in the evaluation of magnetic resonance imaging guided focused ultrasound surgery (MRgFUS) in the breast: a Feasibility Study

Lead Applicant: Dr Sarah Vinnicombe

July 2013

Sialoadhesin expression and macrophage phenotyping inrenal tissues of patients with anti-neutrophil antibody (ANCA)- associated vasculitis

Lead Applicant: dana kidder

June 2013

Pilot study of auto-antibodies to tumour associated antigens as markers for colorectal cancer

Lead Applicant: Robert Steele

June 2013

Cellular responses to Bendamustine in chronic lymphocytic leukaemia

Lead Applicant: Shubhra Rastogi

June 2013

Expression of novel p68-encoded miRNAs in HER2+ve breast cancer

Lead Applicant: Frances Fuller-Pace

June 2013

Analysis of Hepatitis C Virus Transmission Networks Connecting Urban Centres in Scotland

Lead Applicant: John Dillon

June 2013

Extension of SDH oncocytoma study to include paraganglioma

Lead Applicant: Stewart Fleming

May 2013

Evaluation of anti-IFITM1 antibodies in breast cancer

Lead Applicant: Ted Hupp

May 2013

Expression of PLK1 and p68 in triple negative breast cancers

Lead Applicant: Frances Fuller-Pace

May 2013

Cdk5 activity in human tumours

Lead Applicant: Calum Sutherland

April 2013

Sialoadhesin expression and macrophage phenotyping in renal tissues of patients with anti-neutrophil cytoplasmic antibody (ANCA) –associated vasculitis

Lead Applicant: dana kidder

April 2013

Validation of microRNA biomarkers in human colorectal tumours and metastases

Lead Applicant: Gillian Smith

April 2013

Investigation of treatment response and relapse in acute promyelocytic leukaemia

Lead Applicant: Richard Dillon

March 2013

Production of normal tissue TMAs

Lead Applicant: Philip Coates

March 2013

Anti-CCP diagnostic assay

Lead Applicant: Karen Anderson

February 2013

Biological and epidemiological insights into HPV related oropharyngeal cancers

Lead Applicant: Athiva Shankar

February 2013

Discrimination of ex-vivo normal skin and basal cell carcinoma using advanced Raman spectroscopy

Lead Applicant: PRAVEEN CHERIYAN ASHOK

February 2013

Investigation of Segmental Overgrowth Disorders

Lead Applicant: Victoria Parker

January 2013

Biomarkers of NRF2 activation in NSCLC

Lead Applicant: Kenny MacLeod

January 2013

Mannose binding lectin deficiency, bacterial infection and disease severity in chronic obstructive pulmonary disease: towards personalised medicine for COPD.

Lead Applicant: COLIN Palmer

January 2013

The role of asparaginyl endopeptidase in EGFR overexpression in head and neck squamous cell carcinoma.

Lead Applicant: Sharon White

January 2013

Significance of Chromosome 9p deletion in renal cell carcinoma

Lead Applicant: Ismail El-Mokadem

January 2013

Discrimination of ex-vivo normal colon and colonic adenocarcinoma using fiber probe based advanced Raman spectroscopy

Lead Applicant: PRAVEEN CHERIYAN ASHOK

January 2013

Comparison of Nicastrin protein expression and p53 mutation status in primary breast cancer

Lead Applicant: alastair Thompson

November 2012

Investigation of p68miRNAs in normal breast tissue

Lead Applicant: Frances Fuller-Pace

November 2012

correlation of cancer cells markers with p53 isoform expression in the Breast Cancer (Roche tumour set)

Lead Applicant: jean-christophe bourdon

October 2012

Immunohistochemical validation of findings from quantative proteomics work in renal cancer (project TR223)

Lead Applicant: Ghulam Nabi

October 2012

Investigating the role of N-WASP in the development and metastasis of colorectal cancer

Lead Applicant: Hayley Morris

September 2012

Characterisation of a recurrent t(1;16) translocation in myeloid malignancy

August 2012

Evaluating tumour sample preservation, integrity and performance: the NeoBIG pilot feasibility Study

August 2012

In-Vivo DNA damage response pathways after IORT for rectal cancer

July 2012

Determining genotypes of potential molar conceptions using Laser micro-dissection of paraffin embedded tissue for Quantitative-fluorescent polymerase chain reaction

July 2012

Does K-Ras mutation status influence 5-FU response?

July 2012

Molecular Pathogenesis of Non-Melanoma Skin Cancers

July 2012

Genes that cause risk of breast cancer - how do polymorphisms affect protein expression in normal and tumour tissue ?

June 2012

Expression of novel p68-encoded miRNAs in breast cancer (

June 2012

Genetic Analysis of the Adenoma-Carcinoma Sequence by Array-CGH

May 2012

The expression and distribution of Wnt signalling components in early and advanced cutaneous SCC-stages.

May 2012

Identification of novel genes in malignant melanoma

May 2012

Molecular signatures for prediction of porgnosis

April 2012

Clinical and patient-reported outcomes in patients with HPV and non HPV related head and neck cancer

April 2012

Case Collections and genetic Analysis of Hidradenitis Suppurativa and Acne Vulgaris

April 2012

Exome chip genotyping in the search for COPD susceptibility variants

March 2012

Identification and Validation of Novel Genes Involved in HDL Metabolism

March 2012

Immunochemistry of gammaH2AX expression after radiotherapy for rectal cancer

March 2012

Clinical and patient-reported outcomes in patients with HPV and non HPV related head and neck cancer: combining immunohistochemistry, routine data linkage and touch screen technology

February 2012

Analysis of Rapid Protein Turnover in Human Tissues

February 2012

Discrimination of ex-vivo normal colon and colonic adenocarcinoma using advanced Raman spectroscopy

February 2012

The role of BCL9 in human HCC

January 2012

Analysis of low frequency coding variants in cardiometabolic traits

January 2012

Is Neutrophil Gelatinase-Associated Lipocalin (NGAL) a Prognostic or Diagnostic Marker for Oral Cancer?

January 2012

Head and neck cancer prognostic study using a quantitiative malignancy index diagnostic system on retrospective archival FFPE tissue

January 2012

p68 and SNIP1 expression in breast cancer and association with cyclin D1 status

January 2012

Expression of PTOV1 in Prostate Cancer

January 2012

ICGC breast cancer genome sequencing

November 2011

Wnt5a in SCC and BCC

November 2011

Hepatitis C virus effect on cancer gene alternative splicing

November 2011

Validating different methods of extracting small RNAs from breast cancer tissues

November 2011

Pilot study to compare gene expression in matched primary colorectal tumours and liver metastases

October 2011

Variant HER-2/CEP17 FISH patterns and associated chromosome abnormalities in breast cancer

October 2011

Normal/tumour differences in miRNA expression in human colorectal tumours

September 2011

Expression of novel p68-encoded miRNAs in breast cancer

September 2011

Adrenal expression of corticosteroid-producing enzymes and associated regulatory molecules.

August 2011

Analysis of HE4 Expression by Immunohistochemistry in FFPE Derived Breast Tumours with BRCA1 Mutation

August 2011

An extension of TR000119 to investigate the role of TES in Breast Cancer.

August 2011

breast cancer genome project

August 2011

Breast Cancer Genome project

August 2011

Validation studies in Haemopoietic Malignancies

August 2011

A preliminary study into the prevalence of respiratory Mycoplasma infections in Tayside

July 2011

A pilot investigation into the feasibility of developing a record-linked database to study the genetics of childhood eczema in primary care

July 2011

Identification of microRNA signatures in colorectal tumours and adenomas

June 2011

Histological evaluation of LKB1 protein expression in primary breast cancer

June 2011

Tissue Bank application for Analysis of HCV treatment Outcomes

June 2011

Actin cytoskeleton remodelling is essential for cutaneous squamous cell carcinoma dissemination

June 2011

Identifying Ovarian Cancers with Loss of BRCA1

June 2011

Expression Profile of Lymphocyte-activation Markers in T-cell non-Hodgkins Lymphoma Responsive to Immune Modulation.

May 2011

Expression of CYP2C8 in lung

April 2011

An extension of Tayside Tissue Bank TR0063 project to explore the relationship between genotype at low-penetrance risk loci, and breast cancer phenotype and outcome.

April 2011

Eosinophillic oesophagitis: An immunohistochemical study of lymphocyte populations in adult and paediatric patients.

April 2011

The p53 2011 project

April 2011

Expression of SNIP1 in cancer tissues

March 2011

Phosphorylation of the p68 RNA helicase in cancer tissues

March 2011

Assessment and validation of in vitro systems for evaluating drug metabolic pathways involving glucuronidation and sulfation

March 2011

The role of OATP1B3 as a therapeutic target in RDEB SCC

March 2011

Expression of Polo-like kinase-1 in breast tumours: correlation with p53 status

January 2011

Genomic characterisation of myelodysplastic syndromes

January 2011

Expression of Mage-A antigens in breast cancer and relationship with p53 status

January 2011

Whole genome sequencing of papillary renal carcinoma

December 2010

Significance of chromosome 9p status in small renal masses

December 2010

The Molecular Pathology of Differentiated Type VIN and Invasive Vulvar Squamous Cell Carcinoma

November 2010

Antibody Validation for MRFAP Using Human Tissue Lysates.

November 2010

Analysis of FOXL2 mutation in gynandroblastomas

November 2010

Prognostic impact of LAIR-1 expression in diffuse large B-cell lymphoma

November 2010

Role of FMN2 in cancer

November 2010

11 beta hydroxysteroid dehydrogenase 2 in tumour angiogenesis

October 2010

Quantitative proteomics analysis in renal cancer

October 2010

WGA of DNA from Colorectal Lesions for ACGH analysis

September 2010

Expression of LRH-1 isoforms in breast cancer

September 2010

Go-DARTs study of diabetes, treatment and outcome.

September 2010

Characterisation of colon pathology by cell marker multiplex with the GenomeLab System

August 2010

Detection of bladder cancer cells in sections using Raman spectroscopy.

August 2010

Analysis of mechanism of initiation of APC wild type adenomas

August 2010

Comparison of gene expression in fresh frozen and FFPE ovarian tumours

August 2010

Sub-microscopic genomic assessment of morphologically atypical variants of acute promyelocytic leukaemia: alter idem or acute myeloid leukaemia with t(15;17)?

July 2010

High-resolution analysis of the neoplastic genome in long-term survivors of minimally-treated elderly acute lymphoblastic leukaemia (a pilot study)

July 2010

Microsatellite instability in collecting duct carcinoma of the kidney

May 2010

Amendment to: The expression of peroxisome proliferator-activated receptor gamma (PPARg) in breast and upper gastro-intestinal cancer.

May 2010

Angiotensinogen promotor polymorphisms and the risk of renal cancer progression

May 2010

X inactivation ratios in normal liver

May 2010

Development of molecular therapies for genodermatoses.

April 2010

A Comparative Evaluation of 3 Human Tissue RNA Extraction Methods

April 2010

p53 mutation and gene expression after chemotherapy

April 2010

ChIP of WT1 on ovarian carcinoma

March 2010

The characterisation of telomere dynamics in Myelodysplastic syndrome

February 2010

Role of RCC1 in genomic instability in diffuse large B and follicular lymphomas

January 2010

Immunohistochemical detection of phospho-epitopes - the effect of tissue ischaemia

January 2010

Application of next generation sequencing to interrogate the transcriptome of atopic skin.

January 2010

Diagnostic Markers for Detection and Monitoring of Oesophageal Disease

December 2009

The expression of peroxisome proliferator-activated receptor gamma (PPARg) in breast and upper gastro-intestinal cancer.

December 2009

Role of RCC1 in genomic instability in diffuse large B and follicular lymphomas

December 2009

Improving the diagnostic yield from axillary node core biopsies in breast cancer patients

November 2009

Oncogenic actions of WT1 on adult neoplasms

November 2009

To develop a cDNA array as a predictive tool for chemoresistance in ovarian cancer

November 2009

Mechanisms of imiquimod induced regression in lentigo maligna

November 2009

Identification of novel genes in malignant melanoma

November 2009

Optical Projection Tomography in Colorectal Polyps

November 2009

Oncoprotein expression in salivary gland tumours

November 2009

Does membrane ER existence in human breast cancers?

October 2009

Identification of novel genes in malignant melanoma

October 2009

CBX8 expression in breast cancer

September 2009

CAncer associated small tRNAs as potential diagnostic tools

September 2009

The APC protein in early tissue changes in gut cancer

September 2009

Early tissue changes in intestinal cancer

September 2009

Detection of phenthiazinium dye derivative in human skin by microscopy.

August 2009

Creation of a tissue microarray for the analysis of prognostic factors in male breast cancer

July 2009

The potential association between germline mutations of microRNA 125a and breast cancer

July 2009

High-resolution imaging combined with conventional systems for improved diagnostic medical ultrasound imaging

June 2009

Identification of novel targets for colorectal cancer using scFV phage display applied to an ex-vivo human organ perfusion system.

June 2009

Expression of Polo-like kinase-1 in breast tumours: correlation with p53 status

June 2009

Test request please ignore

May 2009

PPARdelta signalling in Breast Cancer

May 2009

Genetic determinants of type 2 diabetes, susceptibility, related disease outcomes and response to therapy

May 2009

Barrett's Oesophagus Biomarker study

May 2009

The secretory component receptor: a novel trigger of eosinophil responses in asthma

May 2009

DUSP-9 a marker of hepatic neoplasia?

May 2009

Genomic analysis of human NASH

May 2009

EXPRESSION OF MAGE-A ANTIGENS IN BREAST CANCER AND RELATIONSHIP WITH P53 STATUS

April 2009

Biophotonics approaches to the diagnosis of anogenital neoplasia

April 2009

Investigating the presence of migration-stimulating factor (MSF) within the haematopoietic and lymphoid microenvironment

April 2009

Mechanisms of IQGAP2 gene silencing in hepatic carcinogenesis

March 2009

A Screening Test for Colorectal Cancer

March 2009

Molecular Pathogenesis of Non-Melanoma Skin Cancers

March 2009

Identification of novel genes in melanoma

March 2009

Identification of novel genes in melanoma

March 2009

The value of Interleukins(IL) in predicting the outcome of head and neck cancer

February 2009

Microsatellites and linkage analysis to determine specimen collection error rates in a diagnostic laboratory

February 2009

Laboratory based isolation and growth of normal skin and adipose cells from redundant tissue.

February 2009

BRCA1 Polymorphisms and Mutations in Triple Negative Breast Cancer

February 2009

The role of Protein Tyrosine Phosphatase Receptor Delta in Squamous Cell Skin Cancers

January 2009

Maladaption of Nrf2 to Oxidative stress in the liver

December 2008

Investigating the Molecular Response to IORT in Colorectal Cancer

December 2008

Molecular pathogenesis of non−melanoma skin cancers

December 2008

Highly Accurate Breast Cancer Diagnosis through Integration of Biological Knowledge, Novel Imaging Modalities, and Modelling (HAMAM) – Cohort 1 – analysis of breast cancer imaging data in combination with clinical, pathological and genetic information.

December 2008

Assessing the frequency and significance of t(7;21)(p22;q22) in acute myeloid leukaemia and myelodysplastic syndromes (Collaborative Study with West Midlands Tissue Bank)

November 2008

The function of p63 in B-cell lymphomas

October 2008

ERM (ezrin, radixin, moesin) proteins in oral squamous cell carcinoma

October 2008

Studies of Selected Isolated Human Tissues for Identification of Efficacy, Potency and Mechanisms of Action of Pharmacological Agents

September 2008

Why are cystic fibrosis airways inflamed? Insight into a potential mechanism.

September 2008

GenomeLab GeXP assay of cancer gene targets

August 2008

Molecular analysis of the tumour suppressor gene, TES, in human breast cancer

August 2008

High-resolution imaging combined with conventional systems for improved diagnostic medical ultrasound imaging

July 2008

Laminin 332 processing in squamous cell carcinoma

July 2008

Molecular analysis of the tumour suppressor gene, TES, in human breast cancer

July 2008

The Role of Proteomics in Colorectal Cancer Screening

July 2008

HOX genes in head and neck cancer

July 2008

Filensin expression in Breast Cancer Tissue

July 2008

DNA / RNA Extraction for Tayside Tissue Bank

July 2008

Stoichiometry of phosphorylation of Akt in breast tumours

July 2008

Validation of K-Ras gene amplification in colorectal tumours - comparison with normal tissue

June 2008

Microarray analysis of tamoxifen treated breast cancer

June 2008

Sialodehsin positive macrophage in immune-mediated glomerulonephritis

May 2008

Pin1 expression in Breast cacner

May 2008

SDH mutations in renal oncytoma

May 2008

Hox genes in Head and Neck Cancer

May 2008

A Multi-centric Study of Intracellular Protein Expression in Subcutaneous Panniculitis-like T-cell Lymphoma: Potential for Bio-marker-based Treatment Strategies?

April 2008

Endoglin methylation in breast cacner

April 2008

Accessing anti-centromere antibody positive human serum for use as a research tool.

April 2008

Extension of previous studies into the in vitro response of acute myeloid leukaemia to rimcazole

April 2008

Further validation of biomarkers for molecular sub-classification of colorectal cancer patients

March 2008

Expression of Mage-A antigens in breast cancer and relationship with p53 status

March 2008

Oral cancer and pre-cancer: a retrospective study of markers of disease progression and the role of Human Papilloma Virus

March 2008

CYP450 polymorphisms and tamoxifen treatment in breast cancer

March 2008

Correlation of Transforming Growth factor Beta (TGF-β) and related signaling signatures with breast cancer tumour grade, prognosis and metastasis.

March 2008

Effects of high dose UVA1 phototherapy on cutaneous fibrosis and endothelial cell function in patients with systemic sclerosis

February 2008

A pilot PCR bacterial analysis of resected liver specimens

February 2008

Analysis of mammary tumour models

January 2008

PAS proteins in basal cell carcinoma

January 2008

PAS proteins in basal cell carcinoma

January 2008

Beta-papillomaviruses and immunocompetent keratinocyte skin cancers: Is vaccination feasible?

January 2008

expression of p53 isoforms in liver metastasis derived from colon primary tumour

January 2008

Evaluation of Optical Projection Tomography (OPT) as a diagnostic tool

December 2007

Langerhans cell rich mycosis fungoides

November 2007

Role of Dendritic Cells in the Development of Cutaneous Pseudolymphoma and Cutaneous Marginal Zone Lymphoma

November 2007

ERM proteins in hyperproliferative epithelial disorders associated with HPV infection

November 2007

Linking cytogenetic abnormalities to p53 mutations and clinical outcome in breast cancer

November 2007

Molecular profiling of ovarian tumours - implications for personalised medicine

November 2007

RNA extraction from renal tumours

November 2007

Investigation of TGF-beta signaling in Human Umbilical vein Endothelial Cells

October 2007

Investigating the role of polymorphisms, inluding those in FGFR2, TNRC9 and MAP3KI in breast cancer risk and progression

October 2007

Does RCC1 overexpression dysregulate the spindle attachment checkpoint and promote chromosome instability?

October 2007

Epigenetic targeting of chronic lymphocytic leukaemia in a pre-clinical model

September 2007

Implications of cytochrome P450s for Breast Cancer Development and anti-Cancer Therapy

September 2007

: Analysis of novel genetic and epigenetic changes in breast cancer and identification of novel genotype/ epigenotype: clinical phenotype correlations in breast cancer.

September 2007

Evaluation of Cytochrome P450 CYP1 and CYP2 protein expression in lung tumour and normal tissue

September 2007

Evaluation of Cytochrome P450 CYP1 and CYP2 protein expression in lung tumour and normal tissue

September 2007

Analysis of sep53/cornulin mutations in adenocarcinoma of the oesophagus and squamous carcinoma of the oesophagus

September 2007

Analysis of DUSP9 / Pyst3 expression in endoderm-derived visceral organ tumours

July 2007

Analysis of DUSP9 / Pyst3 expression in endoderm-derived visceral organ tumours

July 2007

Analysis of DUSP9 / Pyst3 expression as a novel predictor of outcome in primary hepatic tumours

July 2007

Elucidating Interactions of Systems that Mediate Xenobiotic Disposition:

July 2007

The role of common genetic variation in breast cancer susceptibility and therapuetic response

July 2007

Investigation of patterns of x chromosome inactivation in different tissues

June 2007

Investigation of patterns of x chromosome inactivation in different tissues

June 2007

CRYAB levels in sera from breast cancer patients

May 2007

Investigating the TGF-Beta Signalling pathway as a modifier for predisposition to breast cancer, and clinical outcome.

May 2007

Oncogenic actions of WT1

May 2007

Pilot study to determine whether human skin expresses certain proteins

April 2007

cMyc:Peroxiredoxin regulation in haemopoiesis

April 2007

Vasculogenesis in Head and Neck Squamous Cell Carcinoma

March 2007

Pilot study to evaluate vascular responses and phospholemman

March 2007

Computed tomography guided fine needle aspiration of lung- does ThinPrep assist?

January 2007

Preclinical study of Med BioGene’s Custom 16-Assay Bioarray for subtyping Leukemia and Lymphoma

December 2006

p53 pathway in tumours

November 2006

Identification and validation of biomarkers for molecular sub-classification of colorectal cancer patients – implications for personalised medicine

November 2006

Analysis of mammary tumour models

October 2006

Gene expression profiling in colorectal cancer

September 2006

Molecular Signatures of Normal Breast Tissues

September 2006

NF-kB expression in breast cancer and breast stroma

July 2006